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. 2017 Nov 29;114(50):E10763–E10771. doi: 10.1073/pnas.1712623114

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Fig. 6. — Influence of epinephrine (Epi) stimulation on SNO proteome in three experimental groups. (A) Venn diagram shows total number of SNO sites identified in Epi-stressed control, dmd^mdx:utrn^+/− and dmd^mdx:utrn^+/−:trpc6^−/−. (B) Four-way comparison of SNO sites observed in WT and dmd^mdx:utrn^+/− myocardium ± Epi. (C) Fold change in S-nitrosylation level comparing dmd^mdx:utrn^+/− with WT. Overall, SNO changes were increased at similar sites in dmd^mdx:utrn^+/− in the presence of Epi. (D) Fold change in S-nitrosylation level comparing dmd^mdx:utrn^+/− (red) with dmd^mdx:utrn^+/−:trpc6^−/− (yellow). While some S-nitrosylation levels declined in individual sites, the overall effect was more modest than observed without Epi. (E) Histogram of the relative percent change in S-nitrosylation between dmd^mdx:utrn^+/− and dmd^mdx:utrn^+/−:trpc6^−/−. Among 90 hyper-SNO sites, 44% were reversed by 30% or more with Trpc6 deletion (yellow), and 22 sites were increased further by 30% or more (green).