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. 2017 Nov 27;114(50):E10667–E10676. doi: 10.1073/pnas.1710506114

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Copyright © 2017 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 7. — A model for Ark1/AuroraB-dependent phosphorylation to regulate the connection between Mis12C and Cnp3/CENP-C to control kinetochore assembly. From interphase (Top), Ark1/Aurora B phosphorylates Dsn1 and enhances the interaction between Mis12C and CENP-C to promote Mis12C assembly. During early mitosis when erroneous kinetochore–microtubule attachment occurs frequently (Bottom), Cnp3/CENP-C is phosphorylated by Ark1/Aurora B to attenuate its binding to Mis12C and destabilize the connection between kinetochore and microtubule. N indicates the amino terminus of CENP-C or Dsn1. P indicates phosphorylation by Aurora B.