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Tumorigenicity of DNAJB1–PRKACA is dependent on the kinase domain. (A) H&E staining of DDC-treated mouse livers transfected with CTNNB1T41A combined with either DNAJB1–PRKACA or kinase-dead DNAJB1–PRKACA (KD; Right). (B) Immunofluorescence costaining for Ki67 (red) and GFP (green). Nuclei are counterstained with DAPI (blue). (C) Quantification of Ki67-positive cells. Error bars represent SD. Two-tailed t test, *P < 0.05. ns, not significant. (Scale bars, 50 μm.)
