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. 2017 Sep 29;14(6):5243–5250. doi: 10.3892/etm.2017.5220

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Schematic representation of the antioxidant chain of C. neoformans and the primary antioxidant enzymes involved. Prx, Trx and Grx systems are major enzymatic antioxidant systems in C. neoformans that regulate redox balance (49–51) that are associated with 2 SODs, Cu/Zn-SOD (SOD1) and Mn-SOD (SOD2), which may convert superoxide to hydrogen peroxide (61). C. neoformans, Cryptococcus neoformans; CAT, catalase; GR, glutathione reductase; Grx, glutaredoxin; GSH, glutathione; GSSG, glutathione disulfide; H₂O₂, hydrogen peroxide; NADPH, nicotinamide adenine dinucleotide phosphate; Nnt, nicotinamide nucleotide transhydrogenase; NO, nitric oxide; NOS, nitric oxide synthase; protein-SNO, protein nitrosylation; protein-SSG, protein glutathionylation; Prx1/2, peroxiredoxin 1/2; SH, thiol; SOD, superoxide dismutase; Trx, thioredoxin; TrxR, thioredoxin reductase.