Table 4.
Overview of results from EWAS analyses for intra-pair difference in change in lung function during the follow-up period (p value < 10−5)
| Lung function measure | Probe | Estimate | p value | Chromosome | Bp (hg19) | Proximal gene | CGI feature | Methylationa of “inferior” twin |
|---|---|---|---|---|---|---|---|---|
| Log-ΔzFEV1-changeIP | cg19484381 | − 0.055 | 1.55E−06 | 6 | 28,890,673 | TRIM27 | Body-shore | Hyper |
| cg27261494 | − 0.081 | 5.77E−06 | 6 | 74,104,097 | DDX43 | TSS200-shore | Hyper | |
| Log-ΔzFVC-changeIP | cg12796186 | − 0.066 | 3.28E−06 | 1 | 10,458,599 | PGD | TSS1500-island | Hyper |
| cg14514174 | − 0.044 | 6.39E−06 | 9 | 99,181,512 | ZNF367 | TSS1500-island | Hyper | |
| ΔzFEV1/FVC-changeIP | cg00552805 | 0.0551 | 9.84E−06 | 7 | 44,119,858 | POLM | Body-shore | Hypo |
| cg06375580 | 0.0449 | 9.25E−06 | 12 | 42,538,820 | GXYLT1 | TSS200-island | Hypo | |
| cg12733656 | 0.0396 | 8.82E−06 | 7 | 6,388,695 | C7orf70 | TSS200-island | Hypo |
Bold indicates significance p < 1 × 10−6. Probes were annotated with the most proximal gene, genomic position Bp (hg19), and CpG island context (CGI feature)
Estimate intra-pair difference in M value (logit-transformed beta), TSS200 region spanning from transcription start site (TSS) to 200 bp upstream of TSS, TSS1500 region spanning from − 200 to − 1500 bp upstream of TSS, 5′UTR 5′ untranslated region, IGR intergenic region, NA not applicable, hyper hyper-methylation, hypo hypo-methylation
aRelative DNA methylation of “inferior” twin compared to “superior” twin