Table 6.

Pathway enrichment analyses for Gene Ontology (GO), KEGG, and Pathway Commons (PC) (separate pathways with BH-corrected p value < 0.1) based on significant findings from EWAS for change in lung function

Lung function measure	Database	Pathway name	No. of genes	Genes	Statistics
Log-ΔzFEV1-changeIP	No significant pathway enrichment results
Log-ΔzFVC-changeIP	No significant pathway enrichment results
ΔzFEV1/FVC-changeIP	GO	Transferase activity	2	GXYLT1 POLM	C = 1641; O = 2; E = 0.23; R = 8.67; rawP = 0.0133; adjP = 0.0399

Bold indicates BH adjP < 0.05

C the number of reference genes in the category; O: the number of genes in the gene set and also in the category, E the expected number in the category, R ratio of enrichment, rawP p value from hypergeometric test, adjP p value adjusted by the multiple test adjustment (BH)