Figure 5.
Endocannabinoid concentrations. The concentrations of (A) AEA, (B) 2-AG, (C) PEA and (D) AA were determined by gas chromatography-mass spectrometry. The concentration of AEA was significantly elevated in the URB597 post-treated group (P<0.01) compared with the other three groups, including the URB597 pre-treated group. For 2-AG and AA, no difference was identified among all four groups. For PEA, the concentration was significantly higher in the URB597 post-treated group compared with colitis model group (#P=0.021), while no different was detected between the other groups. These results indicated that only post-treatment with URB597 maintained increased endocannabinoid concentrations. AEA, arachidonoylethanolamide; 2-AG, 2-arachidonoylglycerol; PEA, palmitoylethanolamide; AA, arachidonic acid.