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. 2017 Oct 3;14(6):5557–5563. doi: 10.3892/etm.2017.5259

Figure 2.

Figure 2.

Overexpression of CD44 increases the proliferation of ovarian cancer cells. The proliferation of SKOV-3 cells at (A) 24 h and (B) 48 h; and OVCAR-3 ovarian cancer cells at (C) 24 h and (D) 48 h in 4 groups was measured by a Cell Counting Kit-8 at 0, 24 and 48 h after viral transfection. The relative tumor cell proliferation rate was calculated by dividing the reading of each group at 24 or 48 h by the baseline reading at 0 h, respectively. Compared with the blank or negative control groups, the CD44 overexpression groups of SKOV-3 and OVCAR-3 cells had an increased proliferation rate at 24 and 48 h. However, overexpression of E-cadherin did not alter the proliferation of SKOV-3 and OVCAR-3 cells. Values are expressed as the mean ± standard error of the mean (n=3/group). ***P<0.001 vs. blank or negative control group. E-cad, epithelial cadherin; NC, negative control; OE, overexpression.