CD44 overexpression increases the adhesion ability of ovarian cancer cells. (A) Images presenting the cells adhering to the endothelial layer in each group (magnification, ×40; Hoechst 33342 stain). (B and C) Relative adhesion ability of SKOV-3 and OVCAR-3 cells. Compared with that in the blank and negative control groups, the adhesion ability of SKOV-3 and OVCAR-3 cells in the CD44 overexpression group was markedly higher. There were no significant differences in adhesion ability between the E-cadherin overexpression group and the blank/negative control group. Values are expressed as the mean ± standard error of the mean (n=3/group). ***P<0.001 vs. blank or negative control group. E-cad, epithelial cadherin; NC, negative control; OE, overexpression.