Figure 4.
MitoKATP promoted the proliferation of hPASMCs through miR-210 signaling. (A) The expression of PCNA was assessed by western blot analysis in hPASMCs subjected to hypoxia for 24 or 48 h. (B) hPASMCs were transfected with miR-210 inhibitor or control for 24 h, then treated with 5-HD or diazoxide and exposed to hypoxia for 48 h. The expression of PCNA was assessed by western blot analysis. MitoKATP, mitochondrial ATP-sensitive potassium channel; hPASMCs, human pulmonary artery smooth muscle cells; miR, microRNA; PCNA, proliferating cell nuclear antigen; 5-HD, 5-hydroxyde-canoate; con, control.