Figure 2.

n-3 PUFA prevents cardiac enlargement in H/M-Sod2^−/− mice. (A) Masson's trichrome staining demonstrated that interstitial fibrosis was markedly ameliorated following n-3 PUFA treatment. (B) Cardiomyocyte diameter was significantly decreased in the H/M-Sod2^−/− mice treated with n-3 PUFA, compared with untreated mice. (C) Following n-3 PUFA treatment, FS was significantly increased. n=5; *P<0.05; **P<0.01. n-3 PUFA, omega-3 polyunsaturated fatty acids; H/M-Sod2^−/−, heart/muscle-specific manganese-superoxide dismutase-deficient mice; FS, fraction shortening; WT, wild type.