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Effect of orally administered GGA on cognitive function in APP/PS1 mice. (A) Y-maze, (B) object recognition and (C) MWM tests were conducted in 12-month-old WT and APP/PS1 mice administered with GGA between the ages of 3–12 months. (D) Platform cross frequencies in the MWM were also measured. &P<0.05 vs. untreated WT mice, *P<0.05 vs. untreated Tg mice. GGA, geranylgeranylacetone; APP/PS1, transgenic mouse strain; MWM, Morris water maze; WT, wild type; Tg, transgenic.
