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Effect of orally administered GGA on Aβ levels in APP/PS1 mice. Levels of soluble (A) Aβ40 and (B) Aβ42 in the brain of WT and APP/PS1 mice administered with GGA were measured by sandwich ELISA. &P<0.05 vs. untreated WT mice, *P<0.05 vs. untreated Tg mice. GGA, geranylgeranylacetone; Aβ, amyloid-β; APP/PS1, transgenic mouse strain; WT, wild type; Tg, transgenic.
