Figure 3.

Effect of orally administered GGA on the levels of Aβ clearance proteins in APP/PS1 mice. Whole cell extracts were prepared from the brains of GGA-treated WT and APP/PS1 mice prior to western blot analysis to measure the levels of (A) LRP-1, (B) RAGE and (C) p-gp expression. α-Tubulin was used as an internal standard. ^&P<0.05 vs. untreated WT mice, *P<0.05 vs. untreated Tg mice. GGA, geranylgeranylacetone; Aβ, amyloid-β; APP/PS1, transgenic mouse strain; WT, wild type; Tg, transgenic; LRP-1, lipoprotein receptor-related protein 1; RAGE, receptor for advanced glycation end products; p-gp, p-glycoprotein.