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. 2017 Oct 9;7(6):1093–1100. doi: 10.3892/mco.2017.1446

Table II.

Univariate and multivariate analyses of factors associated with overall survival.

Univariate analyses Multivariate analyses


Variables Risk ratio (95% CI) P-value Risk ratio (95% CI) P-value
Age (<50 vs. ≥50 years) 1.216 (0.989–1.493) 0.063
Site of lesion (trunk vs. extremities) 0.925 (0.748–1.144) 0.471
Histology 1 (superficial spreading vs. others) 1.921 (1.454–2.539) 0.0001
Histology 2 (nodular vs. others) 0.408 (0.312–0.534) 0.0001
Clark's level (I–III vs. IV–V) 2.679 (1.921–3.738) 0.0001
Breslow's thickness (<2 vs. ≥2 mm) 3.016 (2.156–4.220) 0.0001
Neurotropism (present vs. absent) 3.673 (2.061–6.546) 0.0001
Mitotic rate (≤3 vs. >3/mm2) 2.293 (1.705–3.083) 0.0001
Ulceration (present vs. absent) 2.789 (2.035–3.823) 0.0001
Vertical growth phase (present vs. absent) 12.46 (1.737–89.34) 0.012
LVI (present vs. absent) 2.471 (1.678–3.638) 0.0001 3.001 (1.207–7.459) 0.018
TIL (present vs. absent) 0.890 (0.659–1.201) 0.447
Regression (present vs. absent) 0.730 (0.495–1.077) 0.113
Precursor lesion (present vs. absent) 0.796 (0.536–1.182) 0.258
BRAF (positive vs. negative) 0.927 (0.473–1.815) 0.825
Node 1 (lymph node involvement, yes vs. no) 3.511 (2.630–4.687) 0.0001
Node 2 (no. of involved lymph nodes, 1 vs. ≥2) 1.412 (1.029–1.938) 0.033
Metastasis 1 (presence vs. absence) 9.478 (7.490–11.99) 0.0001
Metastasis 2 (type M1a-b vs. M1c) 1.480 (0.975–2.247) 0.066
Recurrence (yes vs. no) 4.116 (3.324–5.097) 0.0001 10.90 (4.446–26.71) 0.0001
Sex (male vs. female) 0.564 (0.456–0.697) 0.0001 0.708

Bold print indicates statistical significance. CI, confidence interval; LVI, lymphovascular invasion; TIL, tumor-infiltrating lymphocytes.