Table II.
Univariate and multivariate analyses of factors associated with overall survival.
| Univariate analyses | Multivariate analyses | |||
|---|---|---|---|---|
| Variables | Risk ratio (95% CI) | P-value | Risk ratio (95% CI) | P-value |
| Age (<50 vs. ≥50 years) | 1.216 (0.989–1.493) | 0.063 | ||
| Site of lesion (trunk vs. extremities) | 0.925 (0.748–1.144) | 0.471 | ||
| Histology 1 (superficial spreading vs. others) | 1.921 (1.454–2.539) | 0.0001 | ||
| Histology 2 (nodular vs. others) | 0.408 (0.312–0.534) | 0.0001 | ||
| Clark's level (I–III vs. IV–V) | 2.679 (1.921–3.738) | 0.0001 | ||
| Breslow's thickness (<2 vs. ≥2 mm) | 3.016 (2.156–4.220) | 0.0001 | ||
| Neurotropism (present vs. absent) | 3.673 (2.061–6.546) | 0.0001 | ||
| Mitotic rate (≤3 vs. >3/mm2) | 2.293 (1.705–3.083) | 0.0001 | ||
| Ulceration (present vs. absent) | 2.789 (2.035–3.823) | 0.0001 | ||
| Vertical growth phase (present vs. absent) | 12.46 (1.737–89.34) | 0.012 | ||
| LVI (present vs. absent) | 2.471 (1.678–3.638) | 0.0001 | 3.001 (1.207–7.459) | 0.018 |
| TIL (present vs. absent) | 0.890 (0.659–1.201) | 0.447 | ||
| Regression (present vs. absent) | 0.730 (0.495–1.077) | 0.113 | ||
| Precursor lesion (present vs. absent) | 0.796 (0.536–1.182) | 0.258 | ||
| BRAF (positive vs. negative) | 0.927 (0.473–1.815) | 0.825 | ||
| Node 1 (lymph node involvement, yes vs. no) | 3.511 (2.630–4.687) | 0.0001 | ||
| Node 2 (no. of involved lymph nodes, 1 vs. ≥2) | 1.412 (1.029–1.938) | 0.033 | ||
| Metastasis 1 (presence vs. absence) | 9.478 (7.490–11.99) | 0.0001 | ||
| Metastasis 2 (type M1a-b vs. M1c) | 1.480 (0.975–2.247) | 0.066 | ||
| Recurrence (yes vs. no) | 4.116 (3.324–5.097) | 0.0001 | 10.90 (4.446–26.71) | 0.0001 |
| Sex (male vs. female) | 0.564 (0.456–0.697) | 0.0001 | 0.708 | |
Bold print indicates statistical significance. CI, confidence interval; LVI, lymphovascular invasion; TIL, tumor-infiltrating lymphocytes.