Table III.
Univariate and multivariate analysis of variables in association with recurrence-free survival.
| Univariate analyses | Multivariate analyses | |||
|---|---|---|---|---|
| Variables | Risk ratio (95% CI) | P-value | Risk ratio (95% CI) | P-value |
| Age (<50 vs. ≥50 years) | 1.100 (0.893–1.354) | 0.371 | ||
| Site of lesion (trunk vs. extremities) | 0.935 (0.756–1.157) | 0.537 | ||
| Histology 1 (superficial spreading vs. others) | 1.618 (1.239–2.114) | 0.0001 | ||
| Histology 2 (nodular vs. others) | 0.497 (0.380–0.649) | 0.0001 | ||
| Clark's level (I–III vs. IV–V) | 2.408 (1.761–3.292) | 0.0001 | ||
| Breslow's thickness (<2 vs. ≥2 mm) | 3.059 (2.230–4.196) | 0.0001 | ||
| Neurotropism (present vs. absent) | 2.037 (0.993–4.178) | 0.052 | ||
| Mitotic rate (≤3 vs. >3/mm2) | 2.459 (1.859–3.253) | 0.0001 | 1.973 (1.090–3.574) | 0.025 |
| Ulceration (present vs. absent) | 2.833 (2.111–3.803) | 0.0001 | ||
| Vertical growth phase (present vs. absent) | 3.324 (1.352–8.170) | 0.009 | ||
| LVI (present vs. absent) | 2.037 (1.375–3.017) | 0.0001 | ||
| TIL (present vs. absent) | 0.811 (0.610–1.079) | 0.151 | ||
| Regression (present vs. absent) | 0.720 (0.494–1.050) | 0.088 | ||
| Precursor lesion (present vs. absent) | 0.798 (0.546–1.167) | 0.245 | ||
| BRAF (positive vs. negative) | 0.819 (0.454–1.480) | 0.508 | ||
| Node 1 (lymph node involvement, yes vs. no) | 3.035 (2.333–3.948) | 0.0001 | 3.521 (1.893–6.547) | 0.0001 |
| Node 2 (no. of involved lymph nodes, 1 vs. ≥2) | 1.356 (0.994–1.849) | 0.054 | ||
| Metastasis 1 (presence vs. absence) | 2.989 (2.113–4.227) | 0.0001 | ||
| Metastasis 2 (type M1a-b vs. M1c) | 0.667 (0.348–1.279) | 0.223 | ||
| Sex (male vs. female) | 0.594 (0.479–0.735) | 0.0001 | 0.749 | |
Bold print indicates statistical significance. CI, confidence interval; LVI, lymphovascular invasion; TIL, tumor-infiltrating lymphocytes.