Fig. 1.

Pulmonary dysfunction after IR is attenuated by MSCs and EVs. a Schematic of murine lung IR protocol where pulmonary function was measured in WT mice after sham surgery or IR. b-d Significant lung dysfunction occurred after IR as demonstrated by increased airway resistance and pulmonary artery (PA) pressure as well as decreased pulmonary compliance compared to sham controls. Pretreatment with MSCs or EVs resulted in significantly reduced lung dysfunction after IR. n = 6–8/group; *p < 0.05 vs. all