Fig. 3.

Hypothetical energy landscape for unassisted OMP folding. The green surface on the left depicts OMP conformations that may be formed en route to the native state. Non-native intramolecular interactions, and/or interactions with the membrane, may lead to ruggedness in the landscape. The surface on the right shows some possible conformations of self-associated OMPs, which may lead to the formation of ordered amyloid-like or disordered aggregates. How folding factors in the cell influence this landscape remains an open question. The OMP polypeptide chain and the membrane are shown in red and blue, respectively