Table 2.
Clinical and laboratory data from SCLC patients stratified by NLR
| Variables | NLR ≤ 4.55 | NLR > 4.55 | p value | ||
|---|---|---|---|---|---|
| n | n | ||||
| Age (years, ± SD) | 57.61 ± 10.63 | 107 | 60.81 ± 9.70 | 32 | 0.129 |
| Gender (male/female) | 81/26 | 107 | 26/6 | 32 | 0.513 |
| Stage (LD/ED) | 50/57 | 107 | 6/26 | 32 | 0.005** |
| Metastasis (yes/no) | 80/27 | 107 | 28/4 | 32 | 0.129 |
| Brain metastasis (yes/no) | 7/100 | 107 | 2/30 | 32 | 1.000 |
| Bone metastasis (yes/no) | 9/98 | 107 | 6/26 | 32 | 0.111 |
| Liver metastasis (yes/no) | 11/96 | 107 | 9/23 | 32 | 0.020* |
| Adrenal metastasis (yes/no) | 10/97 | 107 | 4/28 | 32 | 0.738 |
| Pleural metastasis (yes/no) | 7/100 | 107 | 5/27 | 32 | 0.147 |
| Lymph node metastasis (yes/no) | 72/35 | 107 | 27/5 | 32 | 0.061 |
| Mediastinal metastasis (yes/no) | 3/104 | 107 | 1/31 | 32 | 1.000 |
| Smoking (never/ever) | 32/75 | 107 | 7/25 | 32 | 0.375 |
| Smoking amount (BI) | 660 (380–970) | 73 | 860 (600–1200) | 25 | 0.031* |
| Family cancer history (yes/no) | 19/48 | 67 | 8/12 | 20 | 0.323 |
| Exposure to cooking oil fume (never/ever) | 32/31 | 63 | 7/12 | 19 | 0.286 |
| Operation (yes/no) | 12/95 | 107 | 2/30 | 32 | 0.413 |
| Radiotherapy (yes/no) | 52/55 | 107 | 9/23 | 32 | 0.041* |
| Chemotherapy (yes/no) | 96/11 | 107 | 24/8 | 32 | 0.043* |
| PLR | 115 (89–165) | 107 | 221 (175–324) | 32 | 0.000*** |
| RBC (1012/L) | 4.49 (4.17–4.88) | 107 | 4.18 (3.47–4.47) | 32 | 0.002** |
| Hb (g/L) | 135 (124–146) | 107 | 120 (106–134) | 32 | 0.001** |
| MCV (fL) | 91.4 (87.8–94.1) | 107 | 92.2 (87.6–93.8) | 32 | 0.906 |
| PLT (109/L) | 181 (138–228) | 107 | 206 (169–289) | 32 | 0.035* |
| WBC (109/L) | 6.13 (5.07–7.23) | 107 | 7.34 (6.34–9.75) | 32 | 0.001** |
| Neutrophil (109/L) | 4.08 (3.00–4.98) | 107 | 5.62 (4.98–7.58) | 32 | 0.000*** |
| Lymphocyte (109/L) | 1.46 (1.22–1.82) | 107 | 0.96 (0.71–1.10) | 32 | 0.000*** |
| Alb (g/L) | 41.2 (38.6–43.6) | 104 | 37.1 (33.0–40.2) | 32 | 0.000*** |
| LDH (U/L) | 193 (175–238) | 102 | 264 (205–360) | 31 | 0.001** |
| ALP (U/L) | 79 (65–95) | 104 | 82 (59–114) | 32 | 0.595 |
| CHO (mmol/L) | 4.46 (4.06–4.90) | 102 | 3.87 (3.30–4.47) | 31 | 0.000*** |
| TG (mmol/L) | 1.22 (0.88–1.45) | 102 | 1.06 (0.87–1.46) | 31 | 0.661 |
| HDL-C (mmol/L) | 1.25 (1.08–1.54) | 102 | 1.09 (0.94–1.34) | 31 | 0.007** |
| LDL-C (mmol/L) | 2.63 (2.27–3.00) | 102 | 2.23 (1.63–2.72) | 31 | 0.001** |
| CR (μmol/L) | 76.1 (65.3–87.9) | 104 | 67.6 (55.4–83.7) | 32 | 0.082 |
| CEA (ng/ml) | 3.71 (1.80–9.13) | 85 | 3.66 (2.04–10.25) | 29 | 0.747 |
| CYFRA21-1 (ng/ml) | 3.10 (2.27–4.84) | 75 | 4.76 (2.78–7.43) | 26 | 0.017* |
| NSE (ng/ml) | 38.85 (22.86–97.62) | 86 | 71.29 (37.66–113.23) | 26 | 0.034* |
The data are presented as the means ± the SDs or medians (first quartile-third quartile)
*p < 0.05, **p < 0.01, ***p < 0.001
BI Brinkman index, which was calculated by multiplying the number of cigarettes smoked per day by the duration of smoking in years
RBC red blood cell
HB hemoglobin
MCV mean cell volume
PLT platelet
WBC white blood cell
Alb albumin
LDH lactate dehydrogenase
ALP alkaline phosphates
CHO cholesterol
TG triglyceride
HDL-C high density lipoprotein-cholesterol
LDL-C low density lipoprotein-cholesterol
CR creatinine
CEA carcinoembryomic antigen
CYFRA21-1 cytokeratin fragment antigen 21–1
NSE neuron specific enolase