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. 2017 Nov 29;31(1):e00056-17. doi: 10.1128/CMR.00056-17

TABLE 5.

Current Carrion's disease treatment schedules in Perua

Demographic group Phase Illness First-line treatment
 Second-line treatment
Antibiotic(s) Dosec> Interval Duration Route Antibiotic(s) Dosec Interval (h) Duration (days) Route
Childrenb OF Uncomplicated AMC 20 12 h 14 days p.o. CIP 5 12 14 p.o.
CHLd 16.6/10 8 3/11 p.o.
SXT 5 12 14 p.o.
Severe CIP + CRO CIP, 5–7.5 12 h 14 days i.v./p.o. CIP + CAZ CIP, 5–7.5 12 14 i.v./p.o.
CRO, 70 24 he 7–10 days i.v. CAZ, 16.6–33.3 8 7–10 i.v.
CIP + AK CIP, 5–7.5 12 14 i.v./p.o.
AK, 7.5 12 7–10 i.v./i.m.
PW AZM 10 24 h 7 days p.o. RFP 10 24 21–28 p.o.
ERY 7.5–12.5 6 14 p.o.
CIP 5 12 14 p.o.
Teenagers and adults OF Uncomplicated CIP 500 mg 12 h 14 days p.o. AMC 1 g 12 14 p.o.
SXT 800 mg 12 14 p.o.
CHLd 16.6/10 8 3/11 p.o.
Severe CIP + CRO CIPf, 400/200 mg 12 h 3 days/11 days i.v./p.o. CIP + CAZ CIPf, 400/200 mg 12 3/11 i.v./p.o.
CRO, 2 g 24 h 7–10 days i.v. CAZ, 1 g 8 7 i.v.
CIP+AK CIPf, 400/200 mg 12 3/11 i.v./p.o.
AKg, 7.5 12 7–10 i.v./i.m.
PW AZM 500 mg 24 h 7 days p.o. RIF 600 mg 24 21–28 p.o.
ERY 500 mg 6 14 p.o.
CIP 500 mg 12 14 p.o.
Pregnant or breast-feeding women OF Uncomplicated AMC 1 g 12 h 14 days p.o. CHLd 16.6/10 8 3/11 p.o.
SXT 800 mg 12 14 p.o.
AMX 1 g 8 14 p.o.
Severe CRO + CHL CRO 1 g 12 h 10 days i.v. CRO + AK CRO, 1 g 12 10 i.v.
AK, 500 mg 12 7–10 i.v./i.m.
CHLh 1 g/500 mg 8 h/6 h 5 days/11 days i.v./p.o. CAZ + AK CAZ, 1 g 12 10 i.v.
AK, 500 mg 12 7–10 i.v./i.m.
PW AZM 1 g 1 day/1 wki 3 w RFP 600 mg 24 21–28 p.o.
ERY 500 mg 6 14 p.o.
a

Based on current official guidelines (34, 377). Abbreviations: OF, Oroya fever; PW, Peruvian warts; p.o., oral; i.v., intravenous; i.m., intramuscular; AK, amikacin; AMC, amoxicillin plus clavulanic acid; AMX, amoxicillin; AZM, azithromycin; CAZ, ceftazidime; CIP, ciprofloxacin; CRO, ceftriaxone; CHL, chloramphenicol; ERY, erythromycin; RFP, rifampin; SXT, co-trimoxazole.

b

Individuals up to 14 years old or weighing <45 kg (if the weight is higher the teenager/adult guidelines will be followed). Doses for children are reported in milligrams per kilogram of body weight. Note that specific situations or complications may require schedule modifications (34, 377). In addition, for adults/teenagers and for pregnant women when no units are indicated, the doses are reported in milligrams per kilogram of body weight.

c

For amoxicillin plus clavulanic acid or co-trimoxazole, the dose is in reference to the first antibiotic compound of each combination.

d

Fifty milligrams per kilogram per day for 3 days; thereafter, 30 mg/kg/day for 11 days.

e

In the guidelines 70 mg/kg/day is indicated, but no dosage information is provided.

f

Four hundred milligrams every 12 h for 3 days; thereafter, 200 mg every 12 h.

g

The maximum dose is 1.5 g/day.

h

One gram every 8 h for 5 days (i.v.) followed by 500 mg every 6 h for 11 days (p.o., if possible).

i

One gram per day once a week for 3 weeks.