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Representation of the partial regulatory network of the MTBC stringent response. Stress signals trigger poly-P accumulation, activating the two-component Mpr complex. This increases SigE expression, which, in conjunction with the Mpr complex, activates the transcription of relMtb, thereby increasing the concentration of ppGpp. In a positive-feedback loop, ppGpp in turn blocks PPX activity, amplifying the signal and triggering the stringent response.
