TABLE 2.

Approaches explored in order to optimize TB therapy

Method	Pro(s)	Con(s)	References
Intermittent	Shortens treatment, reduces dosage	Emergence of resistance, requires supervision	65–68
High dose	Reduces visits to clinicians, eradicates persisters	Toxicity, tolerance	71, 72
Resuscitation	Tackles persistent cells directly	Uncontrolled resuscitation might cause relapse	73, 74
Immunotherapy adjuvants	Promising approach, reduces toxicity	Unexpected adverse reactions, variable success, more studies required	75–78