Fig. 5.

The changes in frequency versus amplitude of DA induced by 1.0 mg/kg diazepam occur across divergent time-courses. All DA concentration data are plotted across the 120 minute recording session following vehicle (A) and diazepam (B) treatment. (C, D) In comparison to vehicle (left), diazepam decreases mean (+/- SEM) dopamine concentration, an effect that recovered after 100min. (E, F). In comparison to vehicle (left), diazepam increased the mean frequency (+/- SEM) of dopamine release events, an effect that recovered after 50min. (G) Representative color plots and associated DA concentration traces for 1.0 mg/kg diazepam at 1 minute, 60 minutes, and 120 minutes.