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. 2018 Jan;364(1):131–144. doi: 10.1124/jpet.117.243162

Fig. 2.

Fig. 2.

KV7 channel pharmacological activation with ML213 leads to an inhibition of 20 mM KCl-induced phasic contractions in DSM isolated strips. (A) A representative isometric DSM tension recording demonstrating the concentration-dependent inhibition of 20 mM KCl-induced DSM phasic contractions by ML213 (0.1–30 µM). Cumulative concentration-response curves for the inhibitory effects of ML213 on DSM phasic contraction: amplitude (B), muscle force (C), duration (D), and frequency (E) (n = 7, N = 7; *P < 0.05; ***P < 0.001; two-tailed paired Student’s t-test). See Table 1 for potency and maximum efficacy values and Supplemental Fig. 2 for illustration of summary concentration-responses, data for which are shown as the mean ± S.D.