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. Author manuscript; available in PMC: 2018 Jun 19.
Published in final edited form as: Sci Signal. 2017 Dec 19;10(510):eaan4931. doi: 10.1126/scisignal.aan4931

Figure 1. Proliferative Responses of CD4 and CD8 T Cells to IL-2.

Figure 1

(A) S-phase entry of rested CD4+ and CD8+ T-cell blasts was assessed with a 1-hour pulse of ethynyl deoxyuridine (EdU) after the indicated duration of IL-2 stimulation. (B) Cell proliferation after 72 hours of IL-2 stimulation was assessed by dye dilution (Cell Trace Violet) compared to undivided cells sustained with low dose IL-7. Pooled results from 7 independent experiments plotted as mean +/− SEM (A) or representative of 3 independent experiments (B). Time course (A) compared by repeated measures ANOVA (cell type, time and interaction all p<0.0001) with Bonferroni multiple comparison test (significant p<xxx: ** p<0.01, *** p<0.001 for CD4s vs CD8s at a given time point).