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. 2017 Nov 1;67(1):85–97. doi: 10.2337/db17-0367

Figure 2.

Figure 2

Regulation of skeletal muscle transcriptome by Baf60a and Baf60c. A: Morphology of gastrocnemius (left), quadriceps (middle), and soleus (right) muscles from control (Ctrl) and ACKO mice. B: H&E (top) and Laminin B immunofluorescent (bottom) staining of tibialis anterior (TA) muscle sections. C and D: Weight (C) and glycogen content (D) of gastrocnemius (Gast), TA, and EDL muscles from chow-fed control and ACKO mice (n = 4–5). E: Heat map representation of Baf60-regulated genes in skeletal muscle. F: Enrichment score for the downregulated (cluster II, blue) and upregulated (cluster III, yellow) genes in panel E. G: Venn diagram representation of Baf60-regulated genes. H: qPCR analysis of myofiber type (left), lipid metabolism (middle), and glycolysis (right) gene expression in quadriceps muscles in control and ACKO mice (n = 4–5). Data in C, D, and H represent mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.