Figure 5.

REDD1 ablation prevents attenuated OP amplitudes in response to diabetes. At 4 weeks after STZ administration, scotopic ERG responses were recorded from diabetic and nondiabetic wild-type and REDD1-knockout (KO) mice after overnight dark adaptation. A high-pass filter was used to extract OPs from raw ERG recordings. A: Representative OPs elicited from −1.0 cd-s/m² log flash intensity. Summed OP amplitudes are plotted against the stimulus flash intensity for nondiabetic and diabetic wild-type (B) and REDD1-KO mice (C). D: Comparison of the mean difference in summed OP amplitudes for wild-type and REDD1-KO mice. The corresponding implicit times of nondiabetic and diabetic wild-type (E) and REDD1-deficient mice (F) are shown. G: Comparison of the mean difference in summed OP implicit times for wild-type and REDD1-KO mice between nondiabetic and diabetic mice. Values are means ± SE for two independent experiments (n = 8). *P < 0.05 vs. wild-type. Graphs in C and F share the y-axis with B and E, respectively.