Table 3.
Results for the JM | Results for the LMM | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Bayesian analysis | MLE analysis | Estimate | 2.5% | 97.5% | ||||||
Mean | 2.5% | 97.5% | Estimate | 2.5% | 97.5% | |||||
Intercept | 15.080 | 13.700 | 16.410 | 14.901 | 14.267 | 15.509 | 14.589 | 13.208 | 15.969 | |
Time (visit) | −0.863 | −1.105 | −0.628 | −0.902 | −1.024 | −0.795 | −0.574 | −0.803 | −0.344 | |
Baseline HIV viral load (copies ml−1) | ||||||||||
0–500 | 10.040 | 8.495 | 11.550 | 10.035 | 9.115 | 10.956 | 10.520 | 8.974 | 12.066 | |
500–5000 | 6.623 | 5.175 | 8.020 | 6.605 | 5.764 | 7.288 | 6.985 | 5.530 | 8.440 | |
5000–30000 | 2.977 | 1.464 | 4.519 | 2.946 | 1.907 | 3.907 | 3.210 | 1.611 | 4.808 | |
>30000 | Reference | Reference | Reference | |||||||
Baseline HIV symptoms | −0.115 | −0.513 | 0.268 | −0.182 | −0.614 | 0.234 | −0.142 | −0.550 | 0.265 | |
Antiretroviral therapy | −4.653 | −5.485 | −3.814 | −4.815 | −5.719 | −3.990 | −4.760 | −5.600 | −3.920 | |
at baseline | ||||||||||
Time * baseline viral load (copies ml−1) | ||||||||||
0–500 | 0.464 | 0.207 | 0.734 | 0.463 | 0.319 | 0.597 | 0.232 | −0.016 | 0.480 | |
500–5000 | 0.433 | 0.183 | 0.684 | 0.422 | 0.311 | 0.533 | 0.220 | −0.019 | 0.459 | |
5000–30000 | 0.273 | 0.003 | 0.547 | 0.266 | 0.104 | 0.424 | 0.153 | −0.108 | 0.414 | |
>30000 | Reference | Reference | Reference | |||||||
Time * baseline | −0.049 | −0.107 | 0.013 | −0.054 | −0.117 | 0.010 | −0.027 | −0.086 | 0.032 | |
HIV symptoms | ||||||||||
Time * antiretroviral | 0.109 | −0.011 | 0.229 | 0.105 | −0.027 | 0.223 | 0.159 | 0.040 | 0.279 | |
therapy at baseline | ||||||||||
corr(b i1,b i2) | −0.305 | −0.380 | −0.229 | — | — | — | −0.343 | — | — | |
var(b i1) | 29.120 | 26.000 | 32.520 | — | — | — | 29.284 | — | — | |
var(b i2) | 0.539 | 0.467 | 0.622 | — | — | — | 0.450 | — | — | |
|
7.304 | 7.026 | 7.583 | — | — | — | 7.345 | — | — |
For results from the Bayesian approach, we present the posterior mean, standard deviation and 95% credible intervals. For the maximum profile likelihood estimation results, we provide point estimates and 95% confidence intervals.