Table 2. Fixed effects and sources of variance in nested random effects structure for Model 2A where the independent variable is pre-filter iCa²⁺ and dependent variable is post-filter iCa²⁺.

Random effects are assumed to be normally distributed with a mean of zero and S.D. as per values in this table.

Fixed Effect	Effects Estimate	95% C.I.	df	t	p(>|t|)
Intercept	0.082	0.015–0.152	6.242	55.248	<0.001
Pre-Filter [iCa2+]	0.751	0.558–0.942	3.710	8.095	0.002
Random Effects	Model Parameter	Intercept / Slope	Variance	S.D.	% Total Variance
Patient	b0i	(Intercept)	0.0023	0.048	18.5%
	b1i	Pre_Filt_iCa_mmol.L	0.0220	0.148	57.2%
Circuit within Patient	b0ij	(Intercept)	0.0041	0.064	1.1%
	b1ij	Pre_Filt_iCa_mmol.L	0.0299	0.173	10.1%
Citrate.L_BLOOD.Hr	b2k	(Intercept)	0.0002	0.014	0.5%
Residual	eijk	NA	0.0013	0.036	12.6%