Table 1. Demographic and clinical characteristics of women with severe/non-severe pre-eclampsia according to MgSO4 use (N = 631).
| MgSO4 use N = 422 | No MgSO4 use N = 209 | Unadjusted RR (95% CI) | p-value | |
|---|---|---|---|---|
| Demographic and clinical characteristics in index pregnancy | ||||
| Maternal age (yr) | 30.0 [26.0, 35.0] | 33.0 [29.0, 37.0] | - | <0.001 |
| ≤24 | 76 (18.0%) | 17 (8.1%) | 1.26 (1.09, 1.45) | |
| 25–29 | 108 (25.6%) | 44 (21.1%) | 1.09 (0.94, 1.27) | |
| 30–34 | 115 (27.3%) | 62 (29.7%) | Reference | |
| ≥35 | 123 (29.1%) | 86 (41.1%) | 0.91 (0.77, 1.06) | |
| Pre-existing medical conditions | ||||
| Pre-existing hypertension | 87 (20.6%) | 57 (27.3%) | 0.88 (0.76, 1.02) | 0.076 |
| Diabetes mellitus | 9 (2.1%) | 10 (4.8%) | 0.70 (0.44, 1.13) | 0.113 |
| Venous thromboembolism | 2 (0.5%) | 4 (1.9%) | - | 0.097 |
| Nulliparous | 298 (70.6%) | 121 (57.9%) | 1.22 (1.07, 1.38) | 0.002 |
| Singleton pregnancy | 396 (93.8%) | 182 (87.1%) | 1.40 (1.06, 1.85) | 0.006 |
| Previous gestational hypertension | 60 (14.2%) | 52 (24.9%) | 0.84 (0.69, 1.02) | 0.001 |
| Gestational age at enrolment | 26.9 [25.3, 28.0] | 26.6 [25.1, 27.9] | - | 0.098 |
| Blood pressure | ||||
| Peak sBP | 180 [168, 193] | 168 [158, 180] | - | <0.001 |
| Peak dBP | 107 [100, 114] | 100 [95, 109] | - | <0.001 |
| sBP ≥160 or dBP ≥110 mmHg | 388 (91.9%) | 157 (75.1%) | 1.80 (1.38, 2.35) | <0.001 |
| Proteinuria | 408 (96.7%) | 190 (90.9%) | 1.61 (1.08, 2.40) | 0.004 |
| ≥3+ on dipstick or ≥3g/d | 335 (79.4%) | 127 (60.8%) | 1.41 (1.20, 1.65) | <0.001 |
| Maternal Interventions prescribed | ||||
| Bedrest | 311 (73.7%) | 165 (78.9%) | 0.91 (0.81, 1.03) | 0.179 |
| Interventionist carea | 111 (26.3%) | 15 (7.2%) | 1.43 (1.30, 1.57) | <0.001 |
| Maternal transport prior to delivery | 268 (63.5%) | 80 (38.3%) | 1.42 (1.25, 1.60) | <0.001 |
| Any antihypertensive therapy | 388 (91.9%) | 187 (89.5%) | 1.11 (0.89, 1.38) | 0.380 |
| Antenatal corticosteroids | 376 (89.1%) | 156 (74.6%) | 1.52 (1.22, 1.89) | <0.001 |
| Progress after admission & outcomes | ||||
| Severe maternal complications (one/more)b | 163 (38.6%) | 59 (28.2%) | 1.16 (1.04, 1.29) | 0.013 |
| Fetal syndrome of pre-eclampsia (one/more) | 271 (64.2%) | 149 (71.3%) | 0.90 (0.81, 1.01) | 0.09 |
| Abnormal umbilical artery Doppler | 116 (27.5%) | 72 (34.4%) | - | 0.089 |
| Oligohydramnios | 51 (12.1%) | 29 (13.9%) | - | 0.611 |
| Birthweight <10th centile | 130 (30.8%) | 92 (44.0%) | - | 0.001 |
| Stillbirth | 48 (11.4%) | 28 (13.4%) | - | 0.545 |
| Delivered on 1st admission | 372 (88.2%) | 143 (68.4%) | - | <0.001 |
| Indication for delivery | ||||
| Uncontrolled hypertension | 169 (40.0%) | 81 (38.8%) | 1.02 (0.91, 1.14) | 0.821 |
| Maternal pre-eclampsia symptoms | 338 (80.1%) | 75 (35.9%) | <0.001 | |
| Other maternal signs or abnormal pre-eclampsia lab results | 275 (65.2%) | 55 (26.3%) | 3.33 (2.48, 4.46) | <0.001 |
| Latency, enrolment to delivery (d) | 3.0 [1.0, 7.0] | 3.0 [11.0, 34.0] | - | <0.001 |
| Gestational age at delivery (wk) | 27.7 [26.0, 28.7] | 28.7 [27.0, 31.6] | - | <0.001 |
| Mode of delivery | ||||
| Vaginal | 76 (18.0%) | 55 (26.3%) | 0.84 (0.72, 0.98) | 0.021 |
| Caesarean | 346 (82.0%) | 155 (74.2%) | 1.18 (1.01, 1.38) | 0.029 |
| Spontaneous labour | 8 (1.9%) | 24 (11.5%) | 0.49 (0.29, 0.83) | <0.001 |
| Neonatal death prior to or during NICU admission | 32 (7.6%) | 13 (6.2%) | - | 0.644 |
Data presented as N(%) or median [IQR]
dBP (diastolic blood pressure), NICU (neonatal intensive care unit), sBP (systolic blood pressure), wk (weeks)
a Pregnancies that were not expectantly managed.
b See Table B in S2 File for details of severe maternal complications.