Skip to main content
. 2016 Aug 9;1(1):e564. doi: 10.1097/PR9.0000000000000564

Figure 4.

Figure 4.

Effect of Complete Freund's adjuvant (CFA)-induced inflammation on voluntary wheel running behavior. All mice were analyzed continuously for 24-hour basal running and up to 10 days after 20 μL CFA or vehicle unilateral hind paw injection without any interruption. (A) Running distance (in kilometers) of CFA and control mice, which were housed in groups until separation and start of voluntary wheel running analysis. (B, C) Typical running profiles of previously grouped mice at (B) day 1 and (C) day 8 after CFA or vehicle injection. (D) Running distance (in kilometers) of CFA and control mice which were housed individually before the start of voluntary wheel running analysis and typical running profiles of these isolated cohorts at (E) day 1 and (F) day 8 after paw injection of CFA or vehicle. N = 6 mice per group, P < 0.05 indicated by “*” as compared with control group, “†” as compared with basal values within a group, 2-way repeated-measures analysis of variance with post hoc Tukey test. All data points represent mean ± SEM.