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. 2017 Dec 4;52(2):367–378. doi: 10.3892/ijo.2017.4216

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Copyright: © Yan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Nuclear receptor subfamily 4 group A member 1 (NR4A1) impaires mitochondrial metabolism. (A) Changes in cellular ATP production. (B) Changes in the levels of contents of the mitochondrial respiratory complex. NR4A1 had the ability to further reduce the contents of mitochondrial respiratory complex when compared to the tumor necrosis factor α (TNFα) alone group. (C–F) Quantitative analysis of the expression of contents of the mitochondrial respiratory complex. (G and H) The Stat3 and Stat4 respiratory rate, which was the reflection of mitochondrial energy metabolism efficiency. NR4A1 further abated mitochondria-related energy production efficiency. (I) Cellular glucose uptake was further suppressed in response to NR4A1 overexpression when compared to the TNFα alone group. (J) The extracellular lactate was measured using the cell culture medium with lactate assay kit. NR4A1 attenuated the production of lactate. ^*P<0.05 vs. Ctrl group; ^#P<0.05 vs. TNFα group.