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. 2017 Dec 11;23:911–921.

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Copyright © 2017 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.

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Azithromycin prevents calpain activation and Bad upregulation following retinal ischemia/reperfusion. A: Immunoblotting showing the reduced accumulation of calpain-specific 150/145 kDa SBDP and (B) Bcl-2-associated death promoter (Bad) expression levels after 1 and 6 h of reperfusion in the ischemic retina of azithromycin-treated rats compared to vehicle-treated rats. Histograms show the results of densitometric analysis of the bands normalized to the value of actin and expressed as mean ± standard error of the mean (SEM; n = 4 for each group; *p<0.05, ***p<0.001; ANOVA followed by the Tukey-Kramer test for multiple comparisons). AZM = azithromycin-treated rats; VEH = vehicle-treated rats; Rep time = reperfusion time; R = right ischemic eye; L = left eye; MW = molecular weight.