Table 4.

Effect on serum biomarkers and lipid profile against alloxan-induced diabetic complications.

Parameters	TOL	TOL + PJ
Cmax (μg/mL)	90.21 ± 2.49	135.46 ± 1.73a
Tmax (h)	2.32 ± 0.12	1.55 ± 0.18a
AUC total (μg/h mL)	878.73 ± 5.23	1369.59 ± 6.46b
CL (mL/kg h)	65.69 ± 1.42	32.38 ± 1.21c
T1/2 (h)	7.84 ± 0.82	15.92 ± 0.59c
Vd (mL/kg)	560.42 ± 7.34	595.69 ± 5.52
Ka (h−1)	0.77 ± 0.034	1.49 ± 0.11b

All values are mean ± standard error of the mean; n = 8.

^ap < 0.05, ^bp < 0.01, and ^cp < 0.001, when compared to TOL.

AUC, area under time curve; CL, clearance; PJ, pomegranate juice; TOL, tolbutamide.