Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Structure of Insulin and receptor domain. Left panels: The monomeric hormone (A and B chains, top panel) forms zinc-free dimers via anti-parallel association of B chain α-helices and C-terminal β-strands (brown, middle panel); two zinc ions then mediate assembly of three dimers to form classical hexamer (bottom panel). Right panel: μIR domain (blue) complexed with insulin monomer. The interaction takes place via residue TyrB26 (red) located on the B-chain (green).
