Table 4.
Univariate predictors of V̇E/V̇CO2 slope
| b (95% CL) | β (95% CL) | Intercept (95% CL) | R2 (95% CL) | P-value | |
|---|---|---|---|---|---|
|
| |||||
| HFrEF | |||||
| V̇D | 33 (8, 59) | 0.44 (0.11, 0.68) | 29 (18, 41) | 0.20 (−0.03, 0.43) | 0.01 |
| V̇A | 0.26 (−0.40, 0.92) | 0.14 (−0.22, 0.47) | 38 (24, 52) | 0.02 (−0.07, 0.11) | 0.43 |
| PaO2 | 0.11 (−0.18, 0.40) | 0.14 (−0.22, 0.47) | 35 (12, 58) | 0.02 (−0.07, 0.11) | 0.45 |
| PAO2 | 1.29 (0.89, 1.69) | 0.77 (0.58, 0.88) | −100 (−144, −55) | 0.59 (0.39, 0.79) | <0.001 |
| PA-aO2 | 0.19 (−0.10, 0.49) | 0.24 (−0.12, 0.54) | 37 (26, 48) | 0.06 (−0.09, 0.21) | 0.19 |
| DLO2 | 1.41 (−0.16, 2.99) | 0.32 (−0.03, 0.60) | 37 (29, 45) | 0.10 (−0.08, 0.28) | 0.08 |
| PACO2 | −1.37 (−1.87, −0.87) | −0.72 (−0.85, −0.50) | 90 (73, 107) | 0.51 (0.28, 0.74) | <0.001 |
| HCO3− | −1.70 (−2.64, −0.76) | −0.56 (−0.76, −0.26) | 79 (59, 100) | 0.31 (0.06, 0.56) | <0.01 |
| Base excess | −1.44 (−2.48, −0.40) | −0.46 (−0.70, −0.13) | 39 (34, 44) | 0.21 (−0.02, 0.44) | <0.01 |
| HFpEF | |||||
| V̇D | 31 (8, 53) | 0.49 (0.14, 0.73) | 25 (17, 32) | 0.24 (−0.02, 0.50) | <0.01 |
| V̇A | 0.00 (−0.42, 0.44) | 0.01 (−0.37, 0.39) | 34 (25, 44) | 0.00 (0.0, 0.0) | 0.98 |
| PaO2 | −0.03 (−0.24, 0.18) | −0.06 (−0.43, 0.33) | 36 (21, 52) | 0.00 (−0.04, 0.04) | 0.77 |
| PAO2 | 0.92 (0.38, 1.47) | 0.57 (0.24, 0.78) | −65 (−124, −7) | 0.33 (0.06, 0.60) | <0.01 |
| PA-aO2 | 0.13 (−0.08, 0.35) | 0.25 (−0.14, 0.58) | 30 (22, 37) | 0.06 (−0.10, 0.22) | 0.21 |
| DLO2 | 0.95 (−0.09, 1.98) | 0.35 (−0.03, 0.64) | 30 (25, 35) | 0.13 (−0.09, 0.35) | 0.07 |
| PACO2 | −0.80 (−1.40, −0.20) | −0.48 (−0.73, −0.12) | 64 (41, 86) | 0.23 (−0.03, 0.49) | 0.01 |
| HCO3− | −0.40 (−1.66, 0.87) | −0.13 (−0.49, 0.26) | 43 (15, 71) | 0.02 (−0.08, 0.12) | 0.53 |
| Base excess | −0.04 (−1.21, 1.12) | −0.02 (−0.40, 0.36) | 34 (30, 39) | 0.00 (−0.01, 0.01) | 0.94 |
Data are model parameters from univariate linear regressions predicting V̇E/V̇CO2 slope from rest to peak exercise in heart failure with reduced (HFrEF, N=32) or preserved (HFpEF, N=27) ejection fraction. Standardized beta (β). See definition of variables in Table 3 caption.