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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Trends Genet. 2017 Oct 13;34(1):21–29. doi: 10.1016/j.tig.2017.09.009

Figure 1. Robustness within a miRNA pathway.

Figure 1

Genes involved in functions downstream of LET-7 including sorting, targeting, and detection of miRISCs were identified in an enhancer screen using a weak reduction-of-function allele (see text). Reduction in each of these genes alone displayed no severe phenotype. When the heterochronic function of LET-7-miRISC insufficiently limits LIN-41 levels, a burst vulva phenotype is observed.