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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Chem Biol Drug Des. 2017 Jul 19;91(1):5–16. doi: 10.1111/cbdd.13053

Figure 2. The Hot Spots on the A2AAR.

Figure 2

The hot spots for probe-binding in the active (green) [A], intermediate 1 (cyan) [B], intermediate 2 (orange) [C], and inactive (red) [D] conformers are shown. The orthosteric site (OS) is shown in gray, site 1 in purple, site 2 in blue, site 3 yellow, site 4 in orange, and site 5 in cyan.