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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Chem Biol Drug Des. 2017 Jul 19;91(1):5–16. doi: 10.1111/cbdd.13053

Figure 4. Hot spot 2: ‘The G Protein-Coupling Site’.

Figure 4

is located between TM2 (green), TM3 (gray), TM6 (purple), and TM7 (red). The probes in the active [A] and inactive [C] conformers are shown as blue spheres. The key interacting residues for active conformers [B] and inactive conformers [D] are shown as bonds, and the probes that bind to this site are shown as blue bonds.