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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Chem Biol Drug Des. 2017 Jul 19;91(1):5–16. doi: 10.1111/cbdd.13053

Figure 7. Hot spot 5: ‘The Extracellular Cleft’.

Figure 7

is located between TM3 (gray), and TM4 (orange) helices. The probes are shown as cyan spheres [A]. The key interacting residues are shown as bonds [B], and the probes that bind to this site are shown as cyan bonds.