. Author manuscript; available in PMC: 2019 Jan 1.

Published in final edited form as: Chem Biol Drug Des. 2017 Jul 19;91(1):5–16. doi: 10.1111/cbdd.13053

Table 3.

Non-orthosteric sites in the A_2AAR conformers are listed. The site number, location, transmembrane helices and residues are shown.

Site Number	Location	Regions	Residues
1	Intracellular Crevice	TM3/TM4/TM5	I^3.40, F^3.41, L^3.44, A^3.45, D^3.49 (TM3) I^4.45, I^4.48, C^4.49 (TM4) Y112 (ICL1) C^5.46, P^5.50 (TM5)
2	G Protein-Coupling Site	TM2/TM3/TM6/TM7	N39 (ICL1) T^2.39, N^2.40 (TM2) D^3.49, R^3.50 (TM3) H^6.32, S^6.36, F^6.44 (TM6) Y^7.53 (TM7) I292 (C-Term)
3	The Lipid Interface	TM5/TM6	P^5.50, M^5.54 (TM5) V^6.41, F^6.44, W^6.48 (TM6)
4	C-Terminus Cleft	TM1/TM7	L^1.45, G^1.49, L^1.52 (TM1) V^7.47, P^7.50, F^7.51 (TM7)
5	Extracellular Cleft	TM3/TM4	C^3.30, F^3.31, V^3.34 (TM3) L^4.58, G^4.57, F^4.54 (TM4)