Fig. 7.

Melatonin signaled MAPK/ERK pathways to inactivate CREB transcription promoter which reduces the expression of IP3R and VDAC under H₂O₂. a The activation of melatonin on MAPK/ERK. b MAPK/ERK was responsible for the inhibitory role of melatonin on IP3R and VDAC. c Melatonin could reduce the expression of CREB and its activation. SGC-CBP30, the specific inhibitor of CREB pathways. d, e The transcription promoter CREB was the downstream of ERK, which was activated by oxidative stress and contributed to the elevation of IP3R and VDAC. Melatonin impaired the activation of CREB and therefore reduced the IP3R and VDAC. *P < 0.05 vs. control group, #P < 0.05 vs. H₂O₂ group