Table 2.
Baseline lesion areas (cm2) for diffusion-weighted imaging (DWI)-positive lesions.
| Lesions | 3-Gradient direction DWI | 20DWI* | 3ADC | 20ADC* | T2-initial fluid attenuated inversion recovery (inFLAIR) |
|---|---|---|---|---|---|
| N, all | 78 | 76 | 71 | 70 | 63 |
| Range | 0.03–5.88 | 0.05–5.38 | 0.03–5.07 | 0.03–5.31 | 0.05–6.03 |
| Median [interquartile range (IQR)] | 0.26 (0.11–0.59) | 0.34 (0.19–0.79) | 0.23 (0.14–0.60) | 0.24 (0.12–0.63) | 0.31 (0.15–0.80) |
| N, scar | 50 (64%) | 50 (66%) | 49 (69%) | 48 (69%) | 50 (79%) |
| Range, scar | 0.05–5.88 | 0.06–5.38 | 0.03–5.07 | 0.05–5.31 | 0.05–6.03 |
| Range, no scar | 0.03–1.10 | 0.05–1.05 | 0.03–2.17 | 0.03–1.55 | 0.04–1.56 |
| Median (IQR), scar | 0.41 (0.13–0.86) | 0.53 (0.26–1.07) | 0.34 (0.16–1.00) | 0.38 (0.18–0.86) | 0.37 (0.18–0.89) |
| Median (IQR), no scar | 0.17 (0.08–0.22) | 0.21 (0.10–0.27) | 0.17 (0.07–0.23) | 0.12 (0.08–0.18) | 0.20 (0.08–0.89) |
| Pa | P < 0.0001 | P < 0.0001 | P = 0.001 | P < 0.0001 | P < 0.0001 |
117 patients with 149 events completed 3- and 20DWI sequences and 8-week (8w) magnetic resonance imaging.
aMann–Whitney U test for 8-week scar versus no scar.
31 lesion appeared only on 8w-FLAIR (DWI negative), it is in these data but is probably an intercurrent lesion.
*20DWI/apparent diffusion coefficient (ADC) data were unavailable for 5 patients with 6 lesions.
In, initial.