Table 3.
Distribution of zymogen, active, and serpin-inhibited forms of MASP molecules in the steady-state from kinetic simulations.
| Molecule | Variant | Fraction (%) |
|
|---|---|---|---|
| Simulation 1 | Simulation 2 | ||
| MASP-1 | Zymogen | 55.7 | 55.7 |
| Active | 0.016 | 0.016 | |
| Inhibited | 44.3 | 44.3 | |
| MASP-2 | Zymogen | 66.3 | 66.2 |
| Active | 0.00042 | 0.00042 | |
| Inhibited | 33.7 | 33.8 | |
| MASP-3 | Zymogen | 99.3 | 43.8 |
| Active | 0.68 | 56.2 | |
Simulation 1 was performed with measured rate constants. For simulation 2, the rate constant of MASP-3 activation by zymogen MASP-1 was increased by a factor of 200.