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. 2017 Dec 18;10:422. doi: 10.3389/fnmol.2017.00422

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Copyright © 2017 Zhou, Zong, Zhang, Zhang, Zhang, Wu and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ocular hypertension or PNU-282987 did not cause a significant frequency or amplitude change in the miniature glutamatergic excitatory postsynaptic currents (mEPSCs) of RGCs. (A) Recording from a representative normal rat experiment during control conditions, during PNU-282987 application (10 μM) and during recovery. Vertical calibration bar, 10 pA; horizontal calibration bar, 1 s. (B,C) Cumulative probability plots of mEPSC inter-event interval (B) and amplitude (C) before and during application of PNU-282987 (n = 6, Kolmogorov–Smirnov test). (D,E) Summarized data of the frequency (D) and amplitude (E) of the mEPSCs in normal RGCs (n = 6). (F) Recording from a representative glaucomatous rat experiment during control conditions, during PNU-282987 application (10 μM) and during recovery. Vertical calibration bar, 5 pA; horizontal calibration bar, 0.5 s. (G,H) Bar graph illustrating the frequency (G) and peak amplitude (H) of the responses recorded from normal (n = 4 in frequency; n = 6 in amplitude) and glaucomatous (n = 5) RGCs. (I,J) Frequency (1-s bin) and amplitude histograms of the mEPSCs of the trace in (F). (K,L) Summarized data of the frequency (K) and amplitude (L) of the mEPSC in glaucomatous RGCs (n = 6). The results in (D,E,G,H,K,L) are expressed as the mean ± standard error.