Table 3.
Lung morphometry in mechanically ventilated animals.
| NV | VV0 | VV15 | VV22.5 | VV30 | |
|---|---|---|---|---|---|
| Lm (μm) | 96 ± 10 | 89 ± 13 | 89 ± 13 | 70 ± 6*#†§ | 88 ± 15 |
| D2 of Lm (μm) | 152 ± 45 | 131 ± 39 | 120 ± 45 | 82 ± 9* | 117 ± 27 |
| 1/β | 0.66 ± 0.13 | 0.70 ± 0.13 | 0.78 ± 0.14 | 0.85 ± 0.06* | 0.76 ± 0.10 |
Values are mean ± standard deviation (SD) of 7 animals in each group, exposed to elastase and analyzed 5 weeks after the last instillation. NV: non-ventilated; VV0: variable ventilation with 0% coefficient of variability in tidal volume; VV15: variable ventilation with 15% coefficient of variability in tidal volume; VV22.5: variable ventilation with 22.5% coefficient of variability in tidal volume; VV30: variable ventilation with 30% coefficient of variability in tidal volume; Lm: mean linear intercept; D2: central moments of mean linear intercept; 1/β: homogeneity index. Comparisons were performed by one-way analysis of variance followed by Holm-Šídák's multiple comparisons test.
vs. NV (p < 0.05);
vs. VV0 (p < 0.05);
vs. VV15 (p < 0.05);
vs. VV30 (p < 0.05).