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. 2017 Dec 22;7:18073. doi: 10.1038/s41598-017-18287-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Clustering and functions of the developmental transcriptome. (a) Heat-map of Pearson correlations among different RNA-Seq samples. The most representative genes for the developmental phenotype (top 5000 genes) were used for the calculation of correlations (hierarchical clustering with Ward’s linkage). (b) Overview of hippocampus development. The major perinatal developmental stages are indicated to the side of the t-sne plots of 13898 transcripts (almost 40% of the transcriptome) found to change expression in the course of hippocampal development. Orange colored genes share the same stage of highest expression and become clustered in the t-sne plots. (c) Clustering of the developmental transcriptome (RNA-Seq) in the hippocampus (mean, 25^th and 75^th percentiles of the expression normalized to E15 stage). (d) GO comparisons, heatmap of Bonferroni corrected p-values.