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. 2017 Dec 22;7:18061. doi: 10.1038/s41598-017-18328-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fibronectin with 15 Type III binding sites minimally depends on domain mechanical and chemical properties. Histograms for (row 1) the number FN molecules, (row 2) relaxed length, (row 3) stretched length, (row 4) stretched-to-relaxed length ratio, and (row 5) relaxed length-to-thickness ratio are shown for fibronectin with (A) baseline properties; (B) scrambled domain order; constant domain resting stiffness (C) $k_{i}^{0} = κ_{m i n}$ , (D) $k_{i}^{0} = κ_{m e a n}$ , and (E) $k_{i}^{0} = κ_{m a x}$ ; FN-FN binding site exposure threshold ε _t (F) reduced to 7.5 Å and (G) increased to 30 Å. Cumulative probability distributions are shown in (H). Colors correspond with those shown in A–G. Histograms are from 500 simulations (for C,E,F,G) and 1000 simulations (for A,B,D).