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. 2017 Dec 22;7:18045. doi: 10.1038/s41598-017-18404-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genes with decreased expression in PP-KCs and PN-KCs are not similarly altered in whole skin biopsy comparisons. (A,D,G) Comparison of FC estimates from whole skin (vertical axis) and KC comparisons (horizontal axis). (B,E,H) PP/PN-KC-increased genes with the least similar expression changes compared to whole skin (red: FDR < 0.10, FC > 1.50). (C,F,I) PP/PN-KC-decreased genes with the least similar expression changes compared to whole skin (blue: FDR < 0.10, FC < 0.67). (J,K,L) Comparison of FC estimates from KCs to those from (J) LCM-dissected epidermis (GSE26866), (K) an RNA-seq study of 44 patients (GSE41745, GSE54456/GSE63979, GSE66511), and (L) an RNA-seq study of 174 subjects (92 PP, 82 NN; GSE54456).