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. 2017 Dec 22;7:18045. doi: 10.1038/s41598-017-18404-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Early and late differentiation gene expression is reduced in PP- and PN-KCs compared to NN-KCs. (A,B) FPKM and FC estimates for genes with (A) increased expression in LCM-dissected suprabasal epidermis compared to basal epidermis (GSE42114) and (B) increased expression in KCs undergoing differentiation (devitalized dermis model, GSE52651). (C,D) Average FPKM of basal keratin genes KRT5 and KRT14. (E–G) Average FPKM of early differentiation genes KRT1, KRT10 and DSC1. (H–J) Average FPKM of late differentiation genes FLG, LOR and IVL.